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M94A0315.TXT
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1994-10-08
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Document 0315
DOCN M94A0315
TI Endogenous nonecotropic proviruses mapped with oligonucleotide probes
from the long terminal repeat region.
DT 9412
AU Frankel WN; Coffin JM; Jackson Laboratory, Bar Harbor, Maine 04609.
SO Mamm Genome. 1994 May;5(5):275-81. Unique Identifier : AIDSLINE
MED/94355770
AB We characterized endogenous proviruses in C57BL/6J, DBA/2J, and C3H/HeJ
mouse strains with oligonucleotide probes derived from long terminal
repeat (LTR) sequences of three classes of nonecotropic murine leukemia
virus. The segregation of proviral-host DNA junction fragments was
followed in BXH and BXD recombinant inbred (RI) strain sets, and most
fragments mapped readily to defined chromosomal regions. Most of the LTR
fragments appear to correspond to proviruses mapped previously with
oligonucleotide env region probes of the same viral class. At least 22
elements represent new proviral loci, no more than half of which may be
solo LTRs, and an additional six may correspond to proviruses identified
previously with less specific hybridization probes. Together with
proviruses identified previously with env probes, the LTR probe-reactive
elements represent the majority of endogenous murine leukemia proviruses
in the mouse genome.
DE Animal Base Sequence Comparative Study DNA, Viral/*GENETICS Genes,
env Leukemia Viruses, Murine/*GENETICS Mice Mice, Inbred
C3H/GENETICS/*MICROBIOLOGY Mice, Inbred C57BL/GENETICS/*MICROBIOLOGY
Mice, Inbred DBA/GENETICS/*MICROBIOLOGY Molecular Sequence Data
*Oligonucleotide Probes Proviruses/*GENETICS *Repetitive Sequences,
Nucleic Acid Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).